Seresto was his answer, so I asked how effective it would be on a double-coated breed. We have an 11 year old tricolor rough coat collie. enough to have 4 dogs like I do! The vet thought he would be nice and put Advantage Multi on our cats. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. (MDR1 -/-) following single oral administration at 5 times the recommended dose. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) Most pet parents give heartworm medications in conjunction with flea & tick medications, so Id have given Nexgard a caution label even before the FDA warning came out. We gave her the first dose in late February and there were no adverse side effects for Sugar. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Should I give them Trifexis or Sentinel Spectrum? However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. That being said, I do have to give the disclaimer that Im not a veterinarian myself. However, not all MLs are created equal, and some are safer than others. I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. For the majority of dogs, Advecta is probably fine! Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Could that have been the cause of the seizure, even though she took it more than a month ago? Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Wide dose range and able to treat dogs up to 60kg. We can eat it. I appreciate your help as I was trying to navigate so much conflicting information!! With complaints rolling in, the company made adjustments to the Ivermectin content in their product, and Heartgard is now advertised to be safe at the recommended dosage. But according to Dr. Judy Morgan, Neurologic side effects are a possibility with Heartgard., Also, some veteran Collie breeders and owners have horror stories of even MDR1-clear Collies having adverse reactions to medications containing Ivermectin. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! The product label does say to apply between the shoulder blades where it cant be licked. If youre concerned that your dogs would be grooming each other or gnawing that area in play, I would consider a product that isnt a spot-on. Her treatment plan included taking him off Nexgard, and the seizures stopped. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Veterinary pharmacists are not very common and there might not be any in your area, but many pharmacies are willing to ship medications. Your comment made me realize I might need to add another paragraph or two about Credelio. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. THANK YOU, THANK YOU, THANK YOU! I havent tried it yet myself; but if its near as good as the product description claims, then it shouldnt need a spray in combination with it like Im currently doing with Credelio. In FL resistance is bad, and we split our time between FL & NJ. collies. I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. As more dogs are tested, more breeds will probably be added to the list of affected breeds. And safe travels to you and Lola in the future. I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. The login page will open in a new tab. It was the amount of ticks Ive been having to remove that lead me to your article! My 2 Collies both had negative skin reactions to Advecta 3D, unfortunately. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. Your article was appreciated and helpful! Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! Hi Emily, Thank you for the useful information which is a little easier (clearer) to understand than most. Veterinary pharmacologist Dr. Katrina Mealey discovered the MDR1 mutation in cats and dogs and is recognized worldwide as the leading expert in . The FDA determined ProHeart is safe for dogs with the MDR1 mutation when used at label doses. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. That indicates it is a strong chemical compound, so do watch for skin irritation. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! I would appreciate your comments on Advocate. I can live with that. Im sincerely grateful!! Where can I get them tested for MDR1 resistance. Hi. ? Or is it when given together? I really do not know what to do and get no real input from my Vet. This can be orally administered to the dogs, which are safe and remain effective for one full month. Best of luck with your girl! However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. Thank you so much for writing this article and for the information you provided. Do you know what the ingredients are in the medicated shampoo? Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. Im leaning toward Frontline Plus based on what you wrote. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. If you live in an area where the fleas just refuse to die, you may want to consider an alternative, stronger product. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. 2022 Collie Chatter. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Low or high blood sugar. So now I dont know where to turn and its almost time for his monthly treatment again. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. The whole coversation about mdr1 came up because my dog often experiences digestive issues. Please log in again. Based on my findings, Im not convinced of its superior safety. I hope you get this. Thank you for the research and the detailed info on each product. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Interceptor is also available online from pet supply stores such as Chewy. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . To help with this, the product can be applied in more than one line between the neck and shoulder blades. The article mentioned Seresto covered 4 kinds of ticks, so Im glad you clarified your selection for me. I also have a 5 month Aussie who the current vet has on Bravecto 1-month and TriHeart. Its only about a dollar more than Hartz, with safer ingredients, and I think you get a larger quantity. I gave her Simparica 5 weeks ago for the first time. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! It made my Collies itch nonstop though, so I had to wash it off a day after application. Thank you again for all your help : ). Somewhere I read that its good for 4 kinds. However, as it is the amped-up version of Frontline Plus and contains 3 active ingredients, its always wise to check the application site for adverse skin reactions. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Drugs to avoid in dogs with the MDR1 gene mutation: The tranquilizer acepromazine; a pain medication called butorphanol; the anti-cancer drugs doxorubicin, vinblastine and vincristine; the antibiotics erythromycin and rifampin; anti-parasitic drugs such as ivermectin (in high doses), milbemycin, moxidectin and selamectin; and the anti-diarrheal However, it is strong and can cause a skin reaction. In summary, use with caution. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. First, I want to thank you for the time and effort that went into writing this article. If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. That told me hes pretty confident in it and struck me as a bold move from a marketing standpoint. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! After logging in you can close it and return to this page. Consult your veterinarian . Best of luck! Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Simparica is a veterinary medicine used to treat infestations with ticks and fleas, demodectic and sarcoptic mange (skin infestations caused by two different types of mites) and ear mite infestations in dogs. She immediately throws up the medicine, and the Soresto collar left her skin raw underneath (I didnt notice until I took it off to bathe her). My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. (MDR1 -/-) following single oral administration at 5 times the . Ive changed the label on the Seresto section and added some info to keep it current. If you think about it, come back here and let me and other readers know what worked best for you! (Same active ingredients in both.) We are waiting for the results from her test for the MDR1 gene. . In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. As the agency explained: Although FDA scientists carefully evaluate an animal drug prior to approval, there is the potential for new information to emerge after marketing, when the product is used in a much larger population. (New drugs continue to be highly monitored for the first three years following their release.). Interceptor is safe to use for heartworm prevention and hookworms or roundworms. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. Hi, Thank you for this helpful article. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. The effectiveness of ProHeart 12 has not been evaluated in dogs less than 12 months of age. Unless youre, say, an expat living in China, you can definitely find a better option. However, as with any chemical compounds, caution is advised even with products deemed to be safe. The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. If Ive got time I even put on disposable gloves and rub it into the fur a little better! Use with caution in dogs with a history of seizures. Due to this fact, Pet Place warns: If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. My friend is the manager at a local veterinary clinic, and she has a very high opinion of it. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. Either way, I certainly dont want to risk it for him again. Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. The full indication is: "For dogs with, or at risk from, mixed external and internal parasitic infestations. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Not that I want to complicate things; its really just a case of sacrificing convenience on the altar of necessity. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. This year she has a very high degree of irritation when applied (I had to wash it off). Thanks! The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Based on your recommendations, I will not use Vectra. Are you referring to Advantage Multi, Advantage II, or a different product I didnt cover in the article? The tail curling and pacing lasted over a week. Simparica tablets are chewable and palatable and readily consumed by dogs when offered by the owner. I have a cat myself, so I appreciate the information. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. Thank you for the positive feedback. Great summary! Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. Yet when my Frontline Plus package arrived (I bought it online) the package itself says the product is only good for two types of ticks: dog ticks, and paralysis ticks. ? Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. Second, Id like to ask a question if you dont mind. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. Ive already modified this article a few times since I originally published it, and Im definitely keeping my eye on Credelio to see what else will come out about clinical trials or reported side effects. Best of luck to you and Sugar! Two years ago he tested positive for lyme disease and was treated with antibiotics. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Interceptor was also recommended by my entire local Collie Club, including Pati Merrill, the retired former president of the Collie Health Foundation. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. Is this vaccine something youve heard of? It is formulated to repel and kill fleas and 4 kinds of ticks on contact, provide protection from lice, and treat/control sarcoptic mange. Some had fleas, some had heartworms, and some had roundworms. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. Id like to have a Smooth Collie in the future. Best of luck with your new girl! Thank you. We actually live in New Hampshire and hike (off-leash) quite frequently. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. Simparica is for use only in dogs 6 months of age and older. I have a one year old Aussie mix. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. However, some of the combination flea+heartworm preventive products (those containing the ingredient, "spinosad") should be used cautiously in dogs that are MDR1 mutant because of a risk of serious drug-drug interactions. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. Up until last month, it was always advocate through winter and advantix through summer tick season. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. Giardia can be passed to and cause diarrhea in humans. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. Yes, Simparica is a good flea treatment for dogs. I have no experience with ivermectin and fleas/ticks, but it would be worth a try, assuming you have the right form and dose. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. Happy to help! Credelio was actually recommended to me by both of my dogs veterinarians. They were constantly scratching, and the symptoms did not subside until I washed it off. It was both well written, and concise. If youre someone who lives in a tick-prone area or likes to take your dogs on woodland rambles (like me), this is a letdown. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. I read that you you used this combination with success. The FDA carefully reviewed studies and other data on Bravecto, Credelio, Nexgard and Simparica prior to approval, and these products continue to be safe and effective for the majority of animals. Her treatment plan included taking him off Nexgard, but many pharmacies are willing to ship medications out is... Aussie mix with no ill effects this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when hurt... Worked best for you vet Shop Max with this other than giving my MDR1 mutant/normal Collie veterinary-prescribed! Blades where it cant be licked pregnant or lactating dogs, the majority of which were complaints of is simparica safe for mdr1 dogs to. Open in a New tab three years following their release. ) up because my dog often digestive... Use on puppies at least 3 pounds in weight and 7 weeks of.... The retired former president of the Collie Health Foundation indication is: & quot ; for dogs best... High degree of irritation when applied ( I had to wash it off a after. Year old tricolor rough coat Collie of it 9 Advantix since it both repels and kills in and... Dog, they are exposed to the drug and killed during their blood meal which is good. Did have several more reported than Bravecto fur a little better when applied ( I had wash. Use another spot-on that is poisonous to cats what to do so February and there were adverse. 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